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Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.

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Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM.Am J Pathol. 2013 May;182(5):1780-9. doi: 10.1016/j.ajpath.2013.01.051. Epub 2013 Mar 16. PMID: 23506847.

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. More Info »

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

/ / 1 minuto de lectura

Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN.Biol Psychiatry. 2013 Sep 1;74(5):357-66. doi: 10.1016/j.biopsych.2012.12.003. Epub 2013 Jan 8. PMID: 23312564.

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. More Info »

Calpain inhibitor A-705253 mitigates Alzheimer’s disease-like pathology and cognitive decline in aged 3xTgAD mice.

/ / 1 minuto de lectura

Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM.Am J Pathol. 2012 Aug;181(2):616-25. doi: 10.1016/j.ajpath.2012.04.020. Epub 2012 Jun 9. PMID: 22688056.

Calpain inhibitor A-705253 mitigates Alzheimer’s disease-like pathology and cognitive decline in aged 3xTgAD mice. More Info »

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.

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Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A.Acta Neuropathol. 2012 Jan;123(1):53-70. doi: 10.1007/s00401-011-0896-x. Epub

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus. More Info »

Loss of muscarinic M1 receptor exacerbates Alzheimer’s disease-like pathology and cognitive decline.

/ / 1 minuto de lectura

Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM.Am J Pathol. 2011 Aug;179(2):980-91. doi: 10.1016/j.ajpath.2011.04.041. Epub 2011 Jun 23. PMID: 21704011.

Loss of muscarinic M1 receptor exacerbates Alzheimer’s disease-like pathology and cognitive decline. More Info »

Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus.

/ / 1 minuto de lectura

Baglietto-Vargas D, Moreno-Gonzalez I, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A.J Alzheimers Dis. 2010;21(1):119-32. doi: 10.3233/JAD-2010-100066. PMID: 20413859.

Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus. More Info »

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.

/ / 1 minuto de lectura

Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Del Rio JC, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A.J Alzheimers Dis. 2009;18(4):755-76. doi: 10.3233/JAD-2009-1192. PMID: 19661615.

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice. More Info »

Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease.

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Fernandez-Montesinos R, Torres M, Baglietto-Vargas D, Gutierrez A, Gozes I, Vitorica J, Pozo D.J Mol Neurosci. 2010 May;41(1):114-20. doi: 10.1007/s12031-009-9300-x. Epub 2009 Oct 21. PMID: 19844808.

Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease. More Info »

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer’s disease: age-dependent switch in the microglial phenotype from alternative to classic.

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Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J.J Neurosci. 2008 Nov 5;28(45):11650-61. doi: 10.1523/JNEUROSCI.3024-08.2008. PMID: 18987201.

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer’s disease: age-dependent switch in the microglial phenotype from alternative to classic. More Info »

Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.

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Gavilán MP, Revilla E, Pintado C, Castaño A, Vizuete ML, Moreno-González I, Baglietto-Vargas D, Sánchez-Varo R, Vitorica J, Gutiérrez A, Ruano D.J Neurochem. 2007 Nov;103(3):984-96. doi: 10.1111/j.1471-4159.2007.04787.x. Epub 2007 Jul 31.PMID: 17666053.

Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons. More Info »

Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.

/ / 1 minuto de lectura

Caballero C, Jimenez S, Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Gavilan MP, Ramos B, Del Rio JC, Vizuete M, Gutierrez A, Ruano D, Vitorica J.J Neurosci Res. 2007 Mar;85(4):787-97. doi: 10.1002/jnr.21172.PMID: 17243176.

Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice. More Info »

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer’s disease.

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Ramos B, Baglietto-Vargas D, del Rio JC, Moreno-Gonzalez I, Santa-Maria C, Jimenez S, Caballero C, Lopez-Tellez JF, Khan ZU, Ruano D, Gutierrez A, Vitorica J.Neurobiol Aging. 2006 Nov;27(11):1658-72. doi: 10.1016/j.neurobiolaging.2005.09.022. Epub 2005 Nov 3. PMID: 16271420

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer’s disease. More Info »

Postnatal development of the alpha1 containing GABAA receptor subunit in rat hippocampus.

/ / 1 minuto de lectura

Lopez-Tellez JF, Vela J, del Rio JC, Ramos B, Baglietto-Vargas D, Santa-Maria C, Ruano D, Gutierrez A, Vitorica J.Brain Res Dev Brain Res. 2004 Jan 31;148(1):129-41. doi: 10.1016/j.devbrainres.2003.11.010. PMID: 14757527

Postnatal development of the alpha1 containing GABAA receptor subunit in rat hippocampus. More Info »

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