dbaglietto

Human and Mouse Alzheimer’s Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice

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Andreo-Lopez J, Nuñez-Diaz C, Do Huynh K, Nguyen MMT, Da Cunha C, Cantero-Molina FJ, Campos-Moreno C, Zimbone S, Bellia F, Giuffrida ML, Trujillo-Estrada L, Garcia-Leon JA, Bettinetti-Luque M, Gamez N, Valdes C, Morales R, Forner S, Martini

Human and Mouse Alzheimer’s Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice More Info »

Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease

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Bettinetti-Luque M, Trujillo-Estrada L, Garcia-Fuentes E, Andreo-Lopez J, Sanchez-Varo R, Garrido-Sánchez L, Gómez-Mediavilla Á, López MG, Garcia-Caballero M, Gutierrez A, Baglietto-Vargas D. Br J Pharmacol. 2024 Mar;181(6):840-878. doi: 10.1111/bph.16243. Epub 2023 Oct 3. PMID: 37706346

Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease More Info »

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus

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Muñoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, Garcia-Leon JA, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Romero-Molina C, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Gutierrez A, Vitorica J. Acta Neuropathol Commun. 2023 Feb 28;11(1):31. doi:

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus More Info »

Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP

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Rico-Llanos G, Porras-Perales Ó, Escalante S, Vázquez-Calero DB, Valiente L, Castillo MI, Pérez-Tejeiro JM, Baglietto-Vargas D, Becerra J, Reguera JM, Duran I, Csukasi F. Front Immunol. 2022 Nov 18;13:1054962. doi: 10.3389/fimmu.2022.1054962. eCollection 2022. PMID: 36466830 

Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP More Info »

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis

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Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I, Vizuete M, Vitorica J, Baglietto-Vargas D, Gutierrez A. Int J Mol Sci. 2022 May 12;23(10):5404. doi: 10.3390/ijms23105404.

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis More Info »

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model

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Lin X, Chen L, Baglietto-Vargas D, Kamalipour P, Ye Q, LaFerla FM, Nitz DA, Holmes TC, Xu X. Neurobiol Dis. 2022 Jan;162:105562. doi: 10.1016/j.nbd.2021.105562. Epub 2021 Nov 24. PMID: 34838667

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model More Info »

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis

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Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela JJ, De Castro V, Mejias-Ortega M, Gomez-Arboledas A, Jimenez S, Sanchez-Mico MV, Trujillo-Estrada L, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Davila JC, Vitorica J, Gutierrez A. Front Neurosci. 2021 Nov 4;15:752594. doi:

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis More Info »

Miriam Bettinetti Luque has received a prestigious award for presenting the best poster on dementia in the SENC Meeting in Lleida

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(EN) Miriam Bettinetti Luque has received the BJP award for best presenting poster on dementia at the Spanish Society for Neuroscience Meeting in Lleida, Spain

Miriam Bettinetti Luque has received a prestigious award for presenting the best poster on dementia in the SENC Meeting in Lleida More Info »

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease

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Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, Huynh E, da Cunha C, Javonillo DI, Forner S, Martini AC, Sarraf ST, Simmon VF, Baglietto-Vargas D, LaFerla FM. Neurotherapeutics. 2021 Oct;18(4):2468-2483. doi: 10.1007/s13311-021-01143-1. Epub 2021 Nov

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease More Info »

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

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Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A,

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease More Info »

Juana Andreo Lopez is recipient of a prestigious travel fellowship to attend the Alzheimer’s Association International Conference 2021

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(EN) Juana Andreo Lopez has presented the most exciting results from our project in the International Alzheimer’s Meeting in Denver, USA.

Juana Andreo Lopez is recipient of a prestigious travel fellowship to attend the Alzheimer’s Association International Conference 2021 More Info »

MODEL-AD team at University of California, Irvine (UCI) has created an innovative animal model for modeling Late onset Alzheimer’s disease.

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(EN) University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer’s disease.  

MODEL-AD team at University of California, Irvine (UCI) has created an innovative animal model for modeling Late onset Alzheimer’s disease. More Info »

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

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Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ,

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology More Info »

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

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Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. Neuroscientist. 2021 Mar 26:10738584211001753. doi: 10.1177/10738584211001753. Online ahead of print.PMID: 33769131

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches More Info »

Esquema de la conexión entre los malos hábitos alimentarios, las enfermedades metabólicas, la disbiosis y patologías neurodegenerativas.

Drs. Baglietto-Vargas and Sanchez-Varo describe the importance of the diet to maintain the health of the brain.

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(ES) Our eating habits are less and less healthy. These changes affect us negatively, facilitating the development of metabolic diseases. Obesity and diabetes are two very clear examples of these pathologies.

Drs. Baglietto-Vargas and Sanchez-Varo describe the importance of the diet to maintain the health of the brain. More Info »

Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD

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Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT; and The MODEL‐AD; Consortium.

Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD More Info »

Our lab is recipient of one of the 35 research projects that UMA have received from the Spanish Ministry of Science and Innovation.

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(ES) The ministry of Science and Innovation has emitted the provisional resolution of the I+D+I projects of the University of Malaga selected by the 2019 State Research Program, both in the ‘Generation of Knowledge’ modality and ‘Challenges

Our lab is recipient of one of the 35 research projects that UMA have received from the Spanish Ministry of Science and Innovation. More Info »

Dr. Baglietto-Vargas has collaborated with Dr. LaFerla´s team, a recognized group in Alzheimer´s disease, providing an important advance in understanding the role of inflammation in the progression of Alzheimer´s disease.

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(ES) Scientists from the Institute for Memory Impairment and Neurological Disorders (UCIMIND) has provided an important step forward to fight against Alzheimer’s disease.

Dr. Baglietto-Vargas has collaborated with Dr. LaFerla´s team, a recognized group in Alzheimer´s disease, providing an important advance in understanding the role of inflammation in the progression of Alzheimer´s disease. More Info »

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients.

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Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A.Brain Pathol. 2020 Mar;30(2):345-363. doi: 10.1111/bpa.12785. Epub 2019 Oct 9. PMID: 31491047.

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients. More Info »

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease

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Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. Aging Cell. 2020 Mar;19(3):e13118. doi: 10.1111/acel.13118. Epub 2020 Feb 22.PMID: 32087004 Free PMC article.

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease More Info »

Baglietto lab is developing an innovative research program with state-of-the-art techniques and new animal models in Alzheimer´s disease to discover the pathogenic mechanisms of this illness.

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(ES) The University of Malaga has one of the leading groups in Alzheimer’s research with a total of 12 members with two Professors (Dr. A Gutiérrez and JC Davila) and younger researchers.

Baglietto lab is developing an innovative research program with state-of-the-art techniques and new animal models in Alzheimer´s disease to discover the pathogenic mechanisms of this illness. More Info »

David Baglietto Vargas has been awarded with a prestigious program to join the University of Malaga as faculty.

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(ES) The University of Malaga is the Andalusian University that more fellowship has received in the 2018 call for this state program that seeks to attract excellent research talent.

David Baglietto Vargas has been awarded with a prestigious program to join the University of Malaga as faculty. More Info »

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

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Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus More Info »

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease.

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Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM.Aging Cell. 2018 Aug;17(4):e12791. doi: 10.1111/acel.12791. Epub 2018

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease. More Info »

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

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Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM.Aging Cell. 2019 Jun;18(3):e12919. doi: 10.1111/acel.12919. Epub 2019 Feb 27. PMID: 30809950.

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. More Info »

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease.

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Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG.Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. PMID: 29490706

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease. More Info »

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease.

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Baglietto-Vargas D, Sánchez-Mejias E, Navarro V, Jimenez S, Trujillo-Estrada L, Gómez-Arboledas A, Sánchez-Mico M, Sánchez-Varo R, Vizuete M, Dávila JC, García-Verdugo JM, Vitorica J, Gutierrez A.Sci Rep. 2017 Aug 30;7(1):10085. doi: 10.1038/s41598-017-10353-7. PMID: 28855626

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease. More Info »

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

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Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM.J Neurochem. 2015 Sep;134(5):915-26. doi: 10.1111/jnc.13195. Epub 2015 Jul 14. PMID: 26077803

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice More Info »

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model

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Martinez-Coria H, Yeung ST, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM.Brain Res Bull. 2015 Aug;117:10-5. doi: 10.1016/j.brainresbull.2015.07.001. Epub 2015 Jul 7. PMID: 26162480

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model More Info »

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

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Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J Jr, Cotman CW.Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5078-87. doi: 10.1073/pnas.1514486112. Epub 2015 Aug 24. PMID: 26305968

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus More Info »

α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles

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Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM.Am J Pathol. 2014 Feb;184(2):520-9. doi: 10.1016/j.ajpath.2013.10.010. Epub 2013 Nov 19. PMID: 24269557.

α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles More Info »

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology

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Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J.Acta Neuropathol Commun. 2013 Nov 12;1:73. doi: 10.1186/2051-5960-1-73. PMID: 24252759.

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology More Info »

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