dbaglietto

Human and Mouse Alzheimer’s Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice

Andreo-Lopez J, Nuñez-Diaz C, Do Huynh K, Nguyen MMT, Da Cunha C, Cantero-Molina FJ, Campos-Moreno C, Zimbone S, Bellia F, Giuffrida ML, Trujillo-Estrada L, Garcia-Leon JA, Bettinetti-Luque M, Gamez N, Valdes C, Morales R, Forner S, Martini […]

Human and Mouse Alzheimer’s Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice More Info »

Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease

Bettinetti-Luque M, Trujillo-Estrada L, Garcia-Fuentes E, Andreo-Lopez J, Sanchez-Varo R, Garrido-Sánchez L, Gómez-Mediavilla Á, López MG, Garcia-Caballero M, Gutierrez A, Baglietto-Vargas D. Br J Pharmacol. 2024 Mar;181(6):840-878. doi: 10.1111/bph.16243. Epub 2023 Oct 3. PMID: 37706346

Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease More Info »

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus

Muñoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, Garcia-Leon JA, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Romero-Molina C, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Gutierrez A, Vitorica J. Acta Neuropathol Commun. 2023 Feb 28;11(1):31. doi:

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus More Info »

Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP

Rico-Llanos G, Porras-Perales Ó, Escalante S, Vázquez-Calero DB, Valiente L, Castillo MI, Pérez-Tejeiro JM, Baglietto-Vargas D, Becerra J, Reguera JM, Duran I, Csukasi F. Front Immunol. 2022 Nov 18;13:1054962. doi: 10.3389/fimmu.2022.1054962. eCollection 2022. PMID: 36466830 

Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP More Info »

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis.

Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I, Vizuete M, Vitorica J, Baglietto-Vargas D, Gutierrez A. Int J Mol Sci. 2022 May 12;23(10):5404. doi: 10.3390/ijms23105404.

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis. More Info »

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model.

Lin X, Chen L, Baglietto-Vargas D, Kamalipour P, Ye Q, LaFerla FM, Nitz DA, Holmes TC, Xu X. Neurobiol Dis. 2022 Jan;162:105562. doi: 10.1016/j.nbd.2021.105562. Epub 2021 Nov 24. PMID: 34838667

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model. More Info »

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis.

Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela JJ, De Castro V, Mejias-Ortega M, Gomez-Arboledas A, Jimenez S, Sanchez-Mico MV, Trujillo-Estrada L, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Davila JC, Vitorica J, Gutierrez A. Front Neurosci. 2021 Nov 4;15:752594. doi:

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis. More Info »

Miriam Bettinetti Luque ha recibido un prestigioso premio por presentar el mejor poster en demencia en el congreso SENC en Lleida

(EN) Miriam Bettinetti Luque ha recibido el prestigioso premio BJP por el mejor poster en demencia presentado en el congreso de la Sociedad Española de Neurosciencia celebrado del 3 al 5 de Noviembre en Lleida.

Miriam Bettinetti Luque ha recibido un prestigioso premio por presentar el mejor poster en demencia en el congreso SENC en Lleida More Info »

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease.

Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, Huynh E, da Cunha C, Javonillo DI, Forner S, Martini AC, Sarraf ST, Simmon VF, Baglietto-Vargas D, LaFerla FM. Neurotherapeutics. 2021 Oct;18(4):2468-2483. doi: 10.1007/s13311-021-01143-1. Epub 2021 Nov

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease. More Info »

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease.

Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A,

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease. More Info »

Juana Andreo Lopez ha recibido una prestigiosa beca para atender al congreso internacional de la Asociación de Alzheimer 2021

(EN) Juana Andreo Lopez ha presentado los datos más significativos de nuestro proyecto en el congreso internacional  de Alzheimer en Denver, USA.

Juana Andreo Lopez ha recibido una prestigiosa beca para atender al congreso internacional de la Asociación de Alzheimer 2021 More Info »

El consorcio MODEL-AD de la Universidad de California, Irvine (UCI) ha creado un nuevo modelo para el alzheimer de inicio tardío.

(EN) Biólogos de la Universidad de California, Irvine, han desarrollado un nuevo modelo murino, que, a diferencia de sus predecesores, está basado en la forma más común del Alzheimer.

El consorcio MODEL-AD de la Universidad de California, Irvine (UCI) ha creado un nuevo modelo para el alzheimer de inicio tardío. More Info »

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ,

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology More Info »

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. Neuroscientist. 2021 Mar 26:10738584211001753. doi: 10.1177/10738584211001753. Online ahead of print.PMID: 33769131

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches More Info »

Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD

Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT; and The MODEL‐AD; Consortium.

Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD More Info »

Nuestro laboratorio ha sido galardonado con uno de los 35 proyectos de investigación que la UMA ha recibido del Ministerio de Ciencia e Innovación de España

(ES) El Ministerio de Ciencia e Innovación ha emitido las propuestas de resolución provisional de los proyectos de I+D+i de la Universidad de Málaga seleccionados por el Programa Estatal de Investigación 2019, tanto en la modalidad de

Nuestro laboratorio ha sido galardonado con uno de los 35 proyectos de investigación que la UMA ha recibido del Ministerio de Ciencia e Innovación de España More Info »

Dr. Baglietto-Vargas ha colaborado con el equipo de Dr. LaFerla proporcionando un importante avance para entender la implicación de la respuesta inmune en la enfermedad de Alzheimer

(ES) Científicos del ‘Institute for Memory Impairment and Neurological Disorders’ (UCIMIND) han dado un paso más en la lucha contra el alzhéimer.

Dr. Baglietto-Vargas ha colaborado con el equipo de Dr. LaFerla proporcionando un importante avance para entender la implicación de la respuesta inmune en la enfermedad de Alzheimer More Info »

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients.

Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A.Brain Pathol. 2020 Mar;30(2):345-363. doi: 10.1111/bpa.12785. Epub 2019 Oct 9. PMID: 31491047.

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients. More Info »

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease

Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. Aging Cell. 2020 Mar;19(3):e13118. doi: 10.1111/acel.13118. Epub 2020 Feb 22.PMID: 32087004 Free PMC article.

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease More Info »

Baglietto lab está desarrollando un innovador programa de investigación basándose en nuevas técnicas y modelos animales para descubrir los mecanismos patogénicos subyacentes en la enfermedad de Alzheimer.

(ES) La Universidad de Málaga cuenta con uno de los grupos más punteros en la investigación del alzhéimer, formado por un total de 12 miembros, dos catedráticos de universidad (Dra. A. Gutiérrez y Dr. JC Dávila) y

Baglietto lab está desarrollando un innovador programa de investigación basándose en nuevas técnicas y modelos animales para descubrir los mecanismos patogénicos subyacentes en la enfermedad de Alzheimer. More Info »

David Baglietto Vargas ha sido galardonado con un prestigioso programa de incorporación para unirse a la Universidad de Málaga.

(ES) Es la universidad andaluza que más plazas recibió en la convocatoria 2018 de esta ayuda estatal que busca atraer el talento investigador de excelencia.

David Baglietto Vargas ha sido galardonado con un prestigioso programa de incorporación para unirse a la Universidad de Málaga. More Info »

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus More Info »

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease.

Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM.Aging Cell. 2018 Aug;17(4):e12791. doi: 10.1111/acel.12791. Epub 2018

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease. More Info »

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM.Aging Cell. 2019 Jun;18(3):e12919. doi: 10.1111/acel.12919. Epub 2019 Feb 27. PMID: 30809950.

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. More Info »

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease.

Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG.Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. PMID: 29490706

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease. More Info »

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease.

Baglietto-Vargas D, Sánchez-Mejias E, Navarro V, Jimenez S, Trujillo-Estrada L, Gómez-Arboledas A, Sánchez-Mico M, Sánchez-Varo R, Vizuete M, Dávila JC, García-Verdugo JM, Vitorica J, Gutierrez A.Sci Rep. 2017 Aug 30;7(1):10085. doi: 10.1038/s41598-017-10353-7. PMID: 28855626

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease. More Info »

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM.J Neurochem. 2015 Sep;134(5):915-26. doi: 10.1111/jnc.13195. Epub 2015 Jul 14. PMID: 26077803

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice More Info »

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model

Martinez-Coria H, Yeung ST, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM.Brain Res Bull. 2015 Aug;117:10-5. doi: 10.1016/j.brainresbull.2015.07.001. Epub 2015 Jul 7. PMID: 26162480

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model More Info »

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J Jr, Cotman CW.Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5078-87. doi: 10.1073/pnas.1514486112. Epub 2015 Aug 24. PMID: 26305968

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus More Info »

α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles

Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM.Am J Pathol. 2014 Feb;184(2):520-9. doi: 10.1016/j.ajpath.2013.10.010. Epub 2013 Nov 19. PMID: 24269557.

α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles More Info »

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology

Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J.Acta Neuropathol Commun. 2013 Nov 12;1:73. doi: 10.1186/2051-5960-1-73. PMID: 24252759.

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology More Info »

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM.Neurobiol Dis. 2014 Feb;62:407-15. doi: 10.1016/j.nbd.2013.10.019. Epub 2013 Oct 29. PMID: 24176788

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition More Info »

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