Publicaciones

Human and Mouse Alzheimer’s Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice

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Andreo-Lopez J, Nuñez-Diaz C, Do Huynh K, Nguyen MMT, Da Cunha C, Cantero-Molina FJ, Campos-Moreno C, Zimbone S, Bellia F, Giuffrida ML, Trujillo-Estrada L, Garcia-Leon JA, Bettinetti-Luque M, Gamez N, Valdes C, Morales R, Forner S, Martini […]

Human and Mouse Alzheimer’s Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice More Info »

Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease

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Bettinetti-Luque M, Trujillo-Estrada L, Garcia-Fuentes E, Andreo-Lopez J, Sanchez-Varo R, Garrido-Sánchez L, Gómez-Mediavilla Á, López MG, Garcia-Caballero M, Gutierrez A, Baglietto-Vargas D. Br J Pharmacol. 2024 Mar;181(6):840-878. doi: 10.1111/bph.16243. Epub 2023 Oct 3. PMID: 37706346

Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease More Info »

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus

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Muñoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, Garcia-Leon JA, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Romero-Molina C, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Gutierrez A, Vitorica J. Acta Neuropathol Commun. 2023 Feb 28;11(1):31. doi:

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus More Info »

Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP

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Rico-Llanos G, Porras-Perales Ó, Escalante S, Vázquez-Calero DB, Valiente L, Castillo MI, Pérez-Tejeiro JM, Baglietto-Vargas D, Becerra J, Reguera JM, Duran I, Csukasi F. Front Immunol. 2022 Nov 18;13:1054962. doi: 10.3389/fimmu.2022.1054962. eCollection 2022. PMID: 36466830 

Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP More Info »

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis.

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Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I, Vizuete M, Vitorica J, Baglietto-Vargas D, Gutierrez A. Int J Mol Sci. 2022 May 12;23(10):5404. doi: 10.3390/ijms23105404.

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis. More Info »

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model.

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Lin X, Chen L, Baglietto-Vargas D, Kamalipour P, Ye Q, LaFerla FM, Nitz DA, Holmes TC, Xu X. Neurobiol Dis. 2022 Jan;162:105562. doi: 10.1016/j.nbd.2021.105562. Epub 2021 Nov 24. PMID: 34838667

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model. More Info »

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis.

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Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela JJ, De Castro V, Mejias-Ortega M, Gomez-Arboledas A, Jimenez S, Sanchez-Mico MV, Trujillo-Estrada L, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Davila JC, Vitorica J, Gutierrez A. Front Neurosci. 2021 Nov 4;15:752594. doi:

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis. More Info »

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease.

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Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, Huynh E, da Cunha C, Javonillo DI, Forner S, Martini AC, Sarraf ST, Simmon VF, Baglietto-Vargas D, LaFerla FM. Neurotherapeutics. 2021 Oct;18(4):2468-2483. doi: 10.1007/s13311-021-01143-1. Epub 2021 Nov

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease. More Info »

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease.

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Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A,

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease. More Info »

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

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Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ,

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology More Info »

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

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Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. Neuroscientist. 2021 Mar 26:10738584211001753. doi: 10.1177/10738584211001753. Online ahead of print.PMID: 33769131

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches More Info »

Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD

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Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT; and The MODEL‐AD; Consortium.

Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD More Info »

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients.

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Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A.Brain Pathol. 2020 Mar;30(2):345-363. doi: 10.1111/bpa.12785. Epub 2019 Oct 9. PMID: 31491047.

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients. More Info »

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease

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Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. Aging Cell. 2020 Mar;19(3):e13118. doi: 10.1111/acel.13118. Epub 2020 Feb 22.PMID: 32087004 Free PMC article.

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease More Info »

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

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Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus More Info »

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease.

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Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM.Aging Cell. 2018 Aug;17(4):e12791. doi: 10.1111/acel.12791. Epub 2018

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease. More Info »

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

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Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM.Aging Cell. 2019 Jun;18(3):e12919. doi: 10.1111/acel.12919. Epub 2019 Feb 27. PMID: 30809950.

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. More Info »

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease.

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Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG.Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. PMID: 29490706

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease. More Info »

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease.

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Baglietto-Vargas D, Sánchez-Mejias E, Navarro V, Jimenez S, Trujillo-Estrada L, Gómez-Arboledas A, Sánchez-Mico M, Sánchez-Varo R, Vizuete M, Dávila JC, García-Verdugo JM, Vitorica J, Gutierrez A.Sci Rep. 2017 Aug 30;7(1):10085. doi: 10.1038/s41598-017-10353-7. PMID: 28855626

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease. More Info »

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

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Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM.J Neurochem. 2015 Sep;134(5):915-26. doi: 10.1111/jnc.13195. Epub 2015 Jul 14. PMID: 26077803

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice More Info »

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model

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Martinez-Coria H, Yeung ST, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM.Brain Res Bull. 2015 Aug;117:10-5. doi: 10.1016/j.brainresbull.2015.07.001. Epub 2015 Jul 7. PMID: 26162480

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model More Info »

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

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Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J Jr, Cotman CW.Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5078-87. doi: 10.1073/pnas.1514486112. Epub 2015 Aug 24. PMID: 26305968

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus More Info »

α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles

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Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM.Am J Pathol. 2014 Feb;184(2):520-9. doi: 10.1016/j.ajpath.2013.10.010. Epub 2013 Nov 19. PMID: 24269557.

α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles More Info »

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology

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Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J.Acta Neuropathol Commun. 2013 Nov 12;1:73. doi: 10.1186/2051-5960-1-73. PMID: 24252759.

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology More Info »

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

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Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM.Neurobiol Dis. 2014 Feb;62:407-15. doi: 10.1016/j.nbd.2013.10.019. Epub 2013 Oct 29. PMID: 24176788

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition More Info »

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.

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Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM.Am J Pathol. 2013 May;182(5):1780-9. doi: 10.1016/j.ajpath.2013.01.051. Epub 2013 Mar 16. PMID: 23506847.

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. More Info »

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

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Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN.Biol Psychiatry. 2013 Sep 1;74(5):357-66. doi: 10.1016/j.biopsych.2012.12.003. Epub 2013 Jan 8. PMID: 23312564.

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. More Info »

Calpain inhibitor A-705253 mitigates Alzheimer’s disease-like pathology and cognitive decline in aged 3xTgAD mice.

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Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM.Am J Pathol. 2012 Aug;181(2):616-25. doi: 10.1016/j.ajpath.2012.04.020. Epub 2012 Jun 9. PMID: 22688056.

Calpain inhibitor A-705253 mitigates Alzheimer’s disease-like pathology and cognitive decline in aged 3xTgAD mice. More Info »

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.

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Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A.Acta Neuropathol. 2012 Jan;123(1):53-70. doi: 10.1007/s00401-011-0896-x. Epub

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus. More Info »

Loss of muscarinic M1 receptor exacerbates Alzheimer’s disease-like pathology and cognitive decline.

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Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM.Am J Pathol. 2011 Aug;179(2):980-91. doi: 10.1016/j.ajpath.2011.04.041. Epub 2011 Jun 23. PMID: 21704011.

Loss of muscarinic M1 receptor exacerbates Alzheimer’s disease-like pathology and cognitive decline. More Info »

Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus.

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Baglietto-Vargas D, Moreno-Gonzalez I, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A.J Alzheimers Dis. 2010;21(1):119-32. doi: 10.3233/JAD-2010-100066. PMID: 20413859.

Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus. More Info »

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.

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Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Del Rio JC, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A.J Alzheimers Dis. 2009;18(4):755-76. doi: 10.3233/JAD-2009-1192. PMID: 19661615.

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice. More Info »

Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease.

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Fernandez-Montesinos R, Torres M, Baglietto-Vargas D, Gutierrez A, Gozes I, Vitorica J, Pozo D.J Mol Neurosci. 2010 May;41(1):114-20. doi: 10.1007/s12031-009-9300-x. Epub 2009 Oct 21. PMID: 19844808.

Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease. More Info »

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