OUR
Publications
See below our recent publications to understand more about Alzheimer’s disease.
Cerebrovascular alterations in a mouse model of late-onset Alzheimer’s disease
Crouzet C, Xie DF, Laquindanum Nuqui MN, Hasselman J, Phan T, Wilson RH, Baglietto-Vargas D, Da Cunha C, Davtyan H, Forner S, Jullienne A, Bazrafkan A, LaFerla FM, Obenaus A, Blurton-Jones M, Akbari Y, Green KN, Choi B. Neurophotonics. 2025 Jan;12(Suppl 1):S14614. doi: 10.1117/1.NPh.12.S1.S14614. Epub 2025 Jun 5. PMID: 40475700
Human and Mouse Alzheimer’s Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice
Andreo-Lopez J, Nuñez-Diaz C, Do Huynh K, Nguyen MMT, Da Cunha C, Cantero-Molina FJ, Campos-Moreno C, Zimbone S, Bellia F, Giuffrida ML, Trujillo-Estrada L, Garcia-Leon JA, Bettinetti-Luque M, Gamez N, Valdes C, Morales R, Forner S, Martini AC, Gutierrez A, LaFerla FM, Baglietto-Vargas D. Aging Cell. 2025 Aug;24(8):e70094. doi: 10.1111/acel.70094. Epub 2025 May 13. PMID: 40364523
Animal and Cellular Models of Alzheimer’s Disease
Baglietto-Vargas D, Freude KK, Garcia-Leon JA. Biomedicines. 2024 Jun 13;12(6):1308. doi: 10.3390/biomedicines12061308. PMID: 38927515
Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease
Bettinetti-Luque M, Trujillo-Estrada L, Garcia-Fuentes E, Andreo-Lopez J, Sanchez-Varo R, Garrido-Sánchez L, Gómez-Mediavilla Á, López MG, Garcia-Caballero M, Gutierrez A, Baglietto-Vargas D. Br J Pharmacol. 2024 Mar;181(6):840-878. doi: 10.1111/bph.16243. Epub 2023 Oct 3. PMID: 37706346
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
Muñoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, Garcia-Leon JA, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Romero-Molina C, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Gutierrez A, Vitorica J. Acta Neuropathol Commun. 2023 Feb 28;11(1):31. doi: 10.1186/s40478-023-01530-z. PMID: 36855152
Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP
Rico-Llanos G, Porras-Perales Ó, Escalante S, Vázquez-Calero DB, Valiente L, Castillo MI, Pérez-Tejeiro JM, Baglietto-Vargas D, Becerra J, Reguera JM, Duran I, Csukasi F. Front Immunol. 2022 Nov 18;13:1054962. doi: 10.3389/fimmu.2022.1054962. eCollection 2022. PMID: 36466830
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I, Vizuete M, Vitorica J, Baglietto-Vargas D, Gutierrez A. Int J Mol Sci. 2022 May 12;23(10):5404. doi: 10.3390/ijms23105404. PMID: 35628216
Editorial: Metabolic Alterations in Neurodegenerative Disorders
Freude KK, Moreno-Gonzalez I, Rodriguez-Ortiz CJ, Baglietto-Vargas D. Front Aging Neurosci. 2022 Feb 18;14:833109. doi: 10.3389/fnagi.2022.833109. eCollection 2022. PMID: 35250547
Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model
Lin X, Chen L, Baglietto-Vargas D, Kamalipour P, Ye Q, LaFerla FM, Nitz DA, Holmes TC, Xu X. Neurobiol Dis. 2022 Jan;162:105562. doi: 10.1016/j.nbd.2021.105562. Epub 2021 Nov 24. PMID: 34838667
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela JJ, De Castro V, Mejias-Ortega M, Gomez-Arboledas A, Jimenez S, Sanchez-Mico MV, Trujillo-Estrada L, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Davila JC, Vitorica J, Gutierrez A. Front Neurosci. 2021 Nov 4;15:752594. doi: 10.3389/fnins.2021.752594. eCollection 2021. PMID: 34803589
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease
Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, Huynh E, da Cunha C, Javonillo DI, Forner S, Martini AC, Sarraf ST, Simmon VF, Baglietto-Vargas D, LaFerla FM. Neurotherapeutics. 2021 Oct;18(4):2468-2483. doi: 10.1007/s13311-021-01143-1. Epub 2021 Nov 4. PMID: 34738197
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM, Green KN. Sci Data. 2021 Oct 15;8(1):270. doi: 10.1038/s41597-021-01054-y. PMID: 34654824
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology
Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM. Nat Commun. 2021 Apr 23;12(1):2421. doi: 10.1038/s41467-021-22624-z.PMID: 33893290 Free PMC article.
Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches
Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. Neuroscientist. 2021 Mar 26:10738584211001753. doi: 10.1177/10738584211001753. Online ahead of print.PMID: 33769131
Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD
Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT; and The MODEL‐AD; Consortium. Alzheimers Dement (N Y). 2020 Nov 23;6(1):e12110. doi: 10.1002/trc2.12110. eCollection 2020.PMID: 33283040 Free PMC article.
Editorial: Risk Factors for Alzheimer’s Disease
Moreno-Gonzalez I, Morales R, Baglietto-Vargas D, Sanchez-Varo R. Front Aging Neurosci. 2020 May 7;12:124. doi: 10.3389/fnagi.2020.00124. eCollection 2020.PMID: 32457597 Free PMC article. No abstract available.
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients.
Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A.Brain Pathol. 2020 Mar;30(2):345-363. doi: 10.1111/bpa.12785. Epub 2019 Oct 9. PMID: 31491047.
miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease
Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. Aging Cell. 2020 Mar;19(3):e13118. doi: 10.1111/acel.13118. Epub 2020 Feb 22.PMID: 32087004 Free PMC article.
Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer’s disease
Martini AC, Baglietto-Vargas D, Medeiros R, LaFerla FM. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):3917-3919. doi: 10.1073/pnas.1917743117. Epub 2020 Feb 11.PMID: 32047040 Free PMC article. No abstract available.
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus
Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. Sci Rep. 2019 Nov 4;9(1):15936. doi: 10.1038/s41598-019-52324-0.PMID: 31685865 Free PMC article.
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21198-21206. doi: 10.1073/pnas.1914088116. Epub 2019 Sep 30.PMID: 31570577 Free PMC article.
Astrocytes: From the Physiology to the Disease.
Trujillo-Estrada L, Gomez-Arboledas A, Forner S, Martini AC, Gutierrez A, Baglietto-Vargas D, LaFerla FM.Curr Alzheimer Res. 2019;16(8):675-698. doi: 10.2174/1567205016666190830110152.PMID: 31470787 Review.
Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease.
Stimmell AC, Baglietto-Vargas D, Moseley SC, Lapointe V, Thompson LM, LaFerla FM, McNaughton BL, Wilber AA.Sci Rep. 2019 Feb 4;9(1):1311. doi: 10.1038/s41598-018-37151-z. PMID: 30718609.
Past to Future: What Animal Models Have Taught Us About Alzheimer’s Disease.
Martini AC, Forner S, Trujillo-Estrada L, Baglietto-Vargas D, LaFerla FM.J Alzheimers Dis. 2018;64(s1):S365-S378. doi: 10.3233/JAD-179917. PMID: 29504540 Review.
Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease.
Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM.Aging Cell. 2018 Aug;17(4):e12791. doi: 10.1111/acel.12791. Epub 2018 Jun 6. PMID: 29877034.
Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.
Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM.Aging Cell. 2019 Jun;18(3):e12919. doi: 10.1111/acel.12919. Epub 2019 Feb 27. PMID: 30809950.
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease.
Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG.Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. PMID: 29490706
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease.
Baglietto-Vargas D, Sánchez-Mejias E, Navarro V, Jimenez S, Trujillo-Estrada L, Gómez-Arboledas A, Sánchez-Mico M, Sánchez-Varo R, Vizuete M, Dávila JC, García-Verdugo JM, Vitorica J, Gutierrez A.Sci Rep. 2017 Aug 30;7(1):10085. doi: 10.1038/s41598-017-10353-7. PMID: 28855626
Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony
Forner S, Baglietto-Vargas D, Martini AC, Trujillo-Estrada L, LaFerla FM.Trends Neurosci. 2017 Jun;40(6):347-357. doi: 10.1016/j.tins.2017.04.002. Epub 2017 May 8. PMID: 28494972 Review.
Diabetes and Alzheimer’s disease crosstalk
Baglietto-Vargas D, Shi J, Yaeger DM, Ager R, LaFerla FM.Neurosci Biobehav Rev. 2016 May;64:272-87. doi: 10.1016/j.neubiorev.2016.03.005. Epub 2016 Mar 9. PMID: 26969101 Review.