To understand the pathways by which different risk factors causes Alzheimer’s disease, we are developing the following research lines.
Most of Alzheimer’s patients suffer from two to eight comorbidities, which play an important role in the onset and progression of Alzheimer’s disease. Clinical and epidemiological evidences suggest that diabetes and midlife obesity are significant risk factors for Alzheimer’s disease. Thus, our laboratory is investigating the pathways by which these comorbid conditions exacerbates Alzheimer.
Alzheimer’s disease is conceptualized as disease of synaptic failure, thus the lab has great interest in determining how normal synaptic function is deteriorated in Alzheimer’s patients. Moreover, we are investigating how different comorbid conditions such as stress, diabetes and obesity affect cognitive and synaptic processes in Alzheimer’s disease.
Inflammation is a body protective process from infection or injury, however, when it becomes dysregulated can lead to the development of many chronic human diseases, including Alzheimer’s disease. The lab is investigating how diabetes and obesity alters inflammation and became dysregulated in the brain and causes Alzheimer’s disease.
